In celebration of the 50th anniversary of the prestigious journal "Cell," FIAS Fellow Roberto Covino and his co-authors published an article discussing the future of structural and cellular biology. This piece delves into the limitations currently facing structural biology and shines a light on emerging technologies poised to revolutionize our understanding of molecular functions within cells. The authors introduce the concept of the virtual 4D reality of cells, poised to become a pivotal tool in the evolution of structural cell biology, , which is also at the centre of their SCALE excellence concept, which has just been selected for the next application stage..